New Trend! Collagen

COLLAGEN

Collagen and collagen hydrolysates are so fancy todays, you can see adds, images, products with them wherever you turn your head. Clinical studies showed that collagen hydrolysate may protect joints from damage, strengthen joints and reduce the pain from conditions like osteoarthritis and lead to a significant increase in bone mass and improve skin health. Commercial collagen hydrolysate, which is called collagen peptide, is manufactured from bovine, porcine and fish skins.

Collagen is most abundant proteins in humans as well mammals. It makes up 25% of the total proteins in the body. It makes bundles in the form of triple helix (superhelix) formed by the intertwining of three peptide chains. There are an equal number of average 1000 amino acids in each chain. The amino acids in the three chains may be the same, or the same in the two chains and different in the third. One of every 3 amino acids is glycine. Iterative Gly-X-Y formula applies. X is usually proline and Y is OH-proline. OH-proline is produced by prolyl hydroxylase catalysis using vitamin C and alfa-ketoglutarate. If there is Vitamin C deficiency, collagen production is disrupted.

Collagen Products in the market

There is a wide range of collagen products in the market in the form of effervescent, powder mixture, tablet, sachet and single-use liquid shots. Naturally, people are confused, which one should use? Which product is the best?

Firstly you should know your needs to find collagen products suited. Type I and III collagen are the best for skin, tendon, bone; Type II collagen is for joints, cartilage. If you are in need of improve skin firmness, fine wrinkles, then should use Type I,II mixture.

If you don't want to deal with making beverages by dissolving powdered collagen, you can use ready-made liquid forms. if you prefer to take like medicine or vitamin tablets, the tablet and capsule forms are for you. If you like candies, you can buy it in gummy form.

Studies recommend that adults consume between 2.5 to 15 grams of collagen per day to enjoy its health benefits.

Studies show that collagen production decreases by 1% after the age of 40, so it is recommended to be taken externally, especially after the age of 40. In addition to the collagen support, regular skin care should be done which inludes cleaning, tonic, moisturizing with the right skin care products suits your skin type.

Here are the results, conclusions of some researches about collagen intake:

Collagen protein displays a low indispensable amino acid profile, yet as a functional food, collagen is a source of physiologically active peptides and conditionally indispensable amino acids that have the potential to optimize health and address physiological needs posed by aging and exercise. The objective of this study was to determine the maximum level of dietary collagen peptides that can be incorporated in the Western pattern diet while maintaining its indispensable amino acid balance. Iterative PDCAAS calculations showed that a level as high as 36% of collagen peptides can be used as protein substitution in the daily diet while ensuring indispensable amino acid requirements are met. This study suggests that the effective amounts of functional collagen peptides (2.5 to 15 g per day) observed in the literature are below the maximum level of collagen that may be incorporated in the standard American diet.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566836/

Eleven studies with a total of 805 patients were included for review. Eight studies used collagen hydrolysate, 2.5g/d to 10g/d, for 8 to 24 weeks, for the treatment of pressure ulcers, xerosis, skin aging, and cellulite. Two studies used collagen tripeptide, 3g/d for 4 to 12 weeks, with notable improvement in skin elasticity and hydration. Lastly, one study using collagen dipeptide suggested anti-aging efficacy is proportionate to collagen dipeptide content. Conclusions and Relevance: Preliminary results are promising for the short and long-term use of oral collagen supplements for wound healing and skin aging. Oral collagen supplements also increase skin elasticity, hydration, and dermal collagen density. Collagen supplementation is generally safe with no reported adverse events.

https://pubmed.ncbi.nlm.nih.gov/30681787/

After retrieving articles from the databases, 19 studies were selected, with a total of 1,125 participants aged between 20 and 70 years (95% women). In the meta-analysis, a grouped analysis of studies showed favorable results of hydrolyzed collagen supplementation compared with placebo in terms of skin hydration, elasticity, and wrinkles. The findings of improved hydration and elasticity were also confirmed in the subgroup meta-analysis. Based on results, ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging, as it reduces wrinkles and improves skin elasticity and hydration.

https://pubmed.ncbi.nlm.nih.gov/33742704/